SIMON GAYTHER LABORATORY

The research of Simon Gayther, PhD, focuses on four areas: identification of genetic variants that confer susceptibility to hormonal cancers, particularly ovarian cancer, using next-generation sequencing and genotyping technologies; relating germ-linegenetic variation to functional targets throughout the human genome, specifically epigenetic and regulatory profiles enriched in the noncoding genome, and the susceptibility genes that drive cancer development; cell biology modeling of cancer to establish functional mechanisms underlying cancer initiation and development; and clinical translation of this research program, specifically establishing a genetic basis for risk prediction and prevention of cancer, and the identification of novel clinical biomarkers associated with early-stage pathogenesis of disease.

GROUPS

FUNCTIONAL GENOMICS AND GWAS

CELL BIOLOGY AND MOLECULAR CARCINOGENESIS GROUP

GENETIC EPIDEMIOLOGY AND VARIANT DISCOVERY

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